E-viri
Recenzirano
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Diekmann, Fritz; Andrés, Amado; Oppenheimer, Federico
Transplantation reviews (Philadelphia, Pa.), 2012, 2012-Jan, 2012-1-00, 20120101, Letnik: 26, Številka: 1Journal Article
Abstract The use of mammalian target of rapamycin inhibitor (mTOR-I) after kidney transplantation has been associated with a higher incidence of proteinuria compared with calcineurin inhibitors (CNIs). This review will focus on mTOR-I–associated proteinuria in different settings after kidney transplantation: de novo mTOR-I treatment in combination with CNI, de novo mTOR-I–containing and CNI-free treatment, early conversion from a CNI-based regimen to an mTOR-I–based regimen, and late conversion. Some possible mechanisms of mTOR-I–induced proteinuria will also be reviewed.
