Cadmium (Cd) is considered a toxic heavy metal; nevertheless, its toxicity fluctuates for different organisms. Cadmium‐tolerant bacteria (CdtB) are diverse and non‐phylogenetically related. Because of their ecological importance these bacteria become particularly relevant when pollution occurs and where human health is impacted. The aim of this review is to show the significance, culturable diversity, metabolic detoxification mechanisms of CdtB and their current uses in several bioremediation processes applied to agricultural soils. Further discussion addressed the technological devices and the possible advantages of genetically modified CdtB for diagnostic purposes in the future. Significance and Impact of the Study: Crop production is adversely affected by the presence of heavy metals in soils dedicated to agriculture. These metals ultimately accumulate in seeds or edible parts and enter the human food chain. The application of cadmium (Cd)‐tolerant bacteria capacities for Cd immobilization and sequestration, in combination with soil management and implementation of other agronomic practices, may reduce the Cd levels in farmlands.