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Sherr, Jennifer L; Bode, Bruce W; Forlenza, Gregory P; Laffel, Lori M; Schoelwer, Melissa J; Buckingham, Bruce A; Criego, Amy B; DeSalvo, Daniel J; MacLeish, Sarah A; Hansen, David W; Ly, Trang T; Sherr, Jennifer L; Weyman, Kate; Tichy, Eileen; VanName, Michelle; Brei, Michelle; Zgorski, Melinda; Steffen, Amy; Carria, Lori; Bode, Bruce W; Busby, Anna; Forlenza, Gregory P; Wadwa, R Paul; Slover, Robert; Cobry, Erin; Messer, Laurel; Laffel, Lori M; Isganaitis, Elvira; Ambler-Osborn, Louise; Freiner, Emily; Turcotte, Christine; Volkening, Lisa; Schoelwer, Melissa; Brown, Sue A; Krauthause, Katie; Emory, Emma; Oliveri, Mary; Buckingham, Bruce A; Ekhlaspour, Laya; Kingman, Ryan; Criego, Amy B; Schwartz, Betsy L; Gandrud, Laura M; Grieme, Aimee; Hyatt, Jamie; DeSalvo, Daniel J; McKay, Siripoom; DeLaO, Kylie; Villegas, Carolina; MacLeish, Sarah A; Wood, Jamie R; Kaminski, Beth A; Casey, Terri; Campbell, Wendy; Behm, Kim; Adams, Ramon; Hansen, David W; Stone, Sheri L; Bzdick, Suzan; Bulger, Jane; Agostini, Lynn; Doolittle, Sarah; Kivilaid, Kaisa; Kleve, Krista; Ly, Trang T; Dumais, Bonnie; Vienneau, Todd; Huyett, Lauren M; Lee, Joon Bok; O'Connor, Jason; Benjamin, Eric
Diabetes care, 08/2022, Letnik: 45, Številka: 8Journal Article
Very young children with type 1 diabetes often struggle to achieve glycemic targets, putting them at risk for long-term complications and creating an immense management burden for caregivers. We conducted the first evaluation of the Omnipod 5 Automated Insulin Delivery System in this population. A total of 80 children aged 2.0-5.9 years used the investigational system in a single-arm study for 13 weeks following 14 days of baseline data collection with their usual therapy. There were no episodes of severe hypoglycemia or diabetic ketoacidosis. By study end, HbA1c decreased by 0.55% (6.0 mmol/mol) (P < 0.0001). Time with sensor glucose levels in target range 70-180 mg/dL increased by 10.9%, or 2.6 h/day (P < 0.0001), while time with levels <70 mg/dL declined by median 0.27% (P = 0.0204). Use of the automated insulin delivery system was safe, and participants experienced improved glycemic measures and reduced hypoglycemia during the study phase compared with baseline.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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