E-viri
Recenzirano
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Lee, Yu-Lin; Liu, Chun-Eng; Cho, Wen-Long; Kuo, Chen-Ling; Cheng, Wen-Ling; Huang, Ching-Shan; Liu, Chin-San
Biomarkers, 03/2014, Letnik: 19, Številka: 2Journal Article
Abstract Objective: Investigate the latent cytomegalovirus (CMV) infection as a biomarker of oxidative stress and atherosclerosis. Methods: Latent CMV infection was diagnosed in healthy individuals with PCR-evidence of CMV DNA in peripheral leucocytes. Oxidative stress and atherosclerosis were measured by mitochondrial DNA oxidative damage index (mtDNAΔCT) and intima media thickness (IMT). Results: The CMV DNA positive subjects had a higher mean mtDNAΔCT and greater IMT than subjects in the control group. Conclusions: Presence of CMV DNA in leucocytes, as a marker of latent CMV infection, was associated with increased levels of oxidative stress and subclinical atherosclerosis in healthy adults.
