E-viri
Recenzirano
Odprti dostop
-
Salonia, Andrea; Pontillo, Marina; Capogrosso, Paolo; Pozzi, Edoardo; Ferrara, Anna Maria; Cotelessa, Alice; Belladelli, Federico; Corsini, Christian; Gregori, Silvia; Rowe, Isaline; Carenzi, Cristina; Ramirez, Giuseppe A.; Tresoldi, Cristina; Locatelli, Massimo; Cavalli, Giulio; Dagna, Lorenzo; Castagna, Antonella; Zangrillo, Alberto; Tresoldi, Moreno; Landoni, Giovanni; Rovere‐Querini, Patrizia; Ciceri, Fabio; Montorsi, Francesco
Andrology, January 2023, Letnik: 11, Številka: 1Journal Article
Background Male patients with COVID‐19 have been found with reduced serum total testosterone (tT) levels and with more severe clinical outcomes. Objectives To assess total testosterone (tT) levels and the probability of recovering eugonadal tT levels during a minimum 12‐month timespan in a cohort of men who have been followed over time after the recovery from laboratory‐confirmed COVID‐19. Materials and methods Demographic, clinical and hormonal values were collected for the overall cohort. Hypogonadism was defined as tT ≤9.2 nmol/l. The Charlson Comorbidity Index was used to score health‐significant comorbidities. Descriptive statistics was used to compare hormonal levels at baseline versus 7‐month (FU1) versus 12‐month (FU2) follow‐up, respectively. Multivariate cox proportional hazards regression model was used to identify the potential predictors of eugonadism recovery over time among patients with hypogonadism at the time of infection. Results Of the original cohort of 286 patients, follow‐up data were available for 121 (42.3%) at FU1 and 63 (22%) patients at FU2, respectively. Higher median interquartile range (IQR) tT levels were detected at FU2 (13.8 (12.3–15.3) nmol/L) versus FU1 (10.2 9.3–10.9 nmol/L) and versus baseline (3.6 3.02–4.02 nmol/L) (all p < 0.0001), whilst both LH and E2 levels significantly decreased over the same time frame (all p ≤ 0.01). Circulating IL‐6 levels further decreased at FU2 compared to FU1 levels (19.3 vs. 72.8 pg/ml) (p = 0.02). At multivariable cox regression analyses, baseline tT level (HR 1.19; p = 0.03 1.02–1.4) was independently associated with the probability of tT level normalization over time, after adjusting for potential confounders. Conclusions Circulating tT levels keep increasing over time in men after COVID‐19. Still, almost 30% of men who recovered from COVID‐19 had low circulating T levels suggestive for a condition of hypogonadism at a minimum 12‐month follow‐up.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.