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Bao, Xiaofeng; Cao, Qiansheng; Xu, Yazhou; Gao, Yuanxue; Xu, Yuan; Nie, Xuemei; Zhou, Baojing; Pang, Tao; Zhu, Jing
Bioorganic & medicinal chemistry, 02/2015, Letnik: 23, Številka: 4Journal Article
Display omitted A new Rhodamine B derivative (RBDPA), namely, N1-(2-(3′,6′-bis(diethylamino)-3-oxospiroisoindoline-1,9′-xanthen-2-yl)ethyl)-N4,N4-bis(pyridin-2-ylmethyl)succinamide, was designed, synthesized and structurally characterized to develop a chemosensor. The studies show that RBDPA exhibits high sensitivity and selectivity toward Al3+ among many other metal cations in an ethanol/H2O (1:1, v/v, pH=7.2, HEPES buffer, 0.1mM) solution. Fluorescence microscopy experiments further demonstrate that RBDPA can be used as a fluorescent probe to detect Al3+ in living cells.
