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Jenberie, Shiferaw; Nordli, Henriette Rogstad; Strandskog, Guro; Greiner-Tollersrud, Linn; Peñaranda, Ma Michelle D.; Jørgensen, Jorunn B.; Jensen, Ingvill
Developmental and comparative immunology, August 2024, 2024-Aug, 2024-08-00, 20240801, Letnik: 157Journal Article
The development and persistence of antibody secreting cells (ASC) after antigenic challenge remain inadequately understood in teleosts. In this study, intraperitoneal (ip) injection of Atlantic salmon (Salmo salar) with salmonid alphavirus (WtSAV3) increased the total ASC response, peaking 3–6 weeks post injection (wpi) locally in the peritoneal cavity (PerC) and in systemic lymphoid tissues, while at 13 wpi the response was only elevated in PerC. At the same time point a specific ASC response was induced by WtSAV3 in PerC and systemic tissues, with the highest frequency in PerC, suggesting a local role. Inactivated SAV (InSAV1) induced comparatively lower ASC responses in all sites, and specific serum antibodies were only induced by WtSAV3 and not by InSAV1. An InSAV1 boost did not increase these responses. Expression of immune marker genes implies a role for PerC adipose tissue in the PerC immune response. Overall, the study suggests the Atlantic salmon PerC as a secondary immune site and an ASC survival niche. •Infection with salmonid alphavirus induced a specific IgM secreting cell response.•The local B cell response in the peritoneal cavity was pronounced and long lasting.•Gene expression suggests peritoneal adipose tissue is involved in the B cell response.•The B cell response to inactivated virus was modest or absent, also after a boost.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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