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Thomsen, Ole Østergaard; Cortot, Antoine; Jewell, Derek; Wright, John P; Winter, Trevor; Veloso, Fernando Tavarela; Vatn, Morten; Persson, Tore; Pettersson, Eva
New England journal of medicine/The New England journal of medicine, 08/1998, Letnik: 339, Številka: 6Journal Article
Crohn's disease is a chronic inflammatory disorder of the bowel whose cause is unknown. During the acute phase of the disease, glucocorticoids such as prednisolone and prednisone are commonly used. 1 , 2 However, this treatment is often associated with clinically important side effects, such as moon face, hirsutism, and acne. Budesonide is a glucocorticoid that is a highly potent topical antiinflammatory agent with lower systemic activity than conventional glucocorticoids, 3 because it is nearly 90 percent metabolized during its first pass through the liver to forms with minimal or no steroidal activity. 3 Budesonide capsules contain granules that allow the slow release of . . .
