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Naaz, Farha; Srivastava, Ritika; Singh, Anuradha; Singh, Nidhi; Verma, Rajesh; Singh, Vishal K.; Singh, Ramendra K.
Bioorganic & medicinal chemistry, 07/2018, Letnik: 26, Številka: 12Journal Article
Display omitted •New heterocyclic sulfonamide analogs synthesized as potential antibacterial agents.•The molecules docked with Bacillus anthracis dihydropteroate synthase enzyme (BaDHPS: PDB ID-3TYE).•Antibacterial activity determined using micro serial dilution method and cytotoxicity using MTT assay.•Fractional inhibitory concentration (FIC) determined using combination approach showed great synergistic effect. A new series of heterocyclic molecules bearing sulfonamide linkage has been synthesized and screened for antibacterial activity. During antibacterial screening using broath dilution method, molecules were found to be highly active (MIC value 50–3.1 µg/mL) against different human pathogens, namely B. cerus, S. aureus, E. coli and P. aeruginosa, and most effective against E. coli. A great synergistic effect was observed during determination of FIC where molecules were used in combination with reference drugs chloramphenicol and sulfamethoxazole. The MIC value of the combination – varying concentration of test compounds and ½ MIC of reference drugs or varying concentration of reference drugs and ½ MIC of test compounds, was reduced up to 1/4 or 1/32 of the original value, indicating thereby the combination was 4–32 times more potent than the test molecule. The molecules also showed low degree of cytotoxicity against PBM, CEM and VERO cell lines. The results positively indicated towards the development of lead antibacterials using the combination approach.
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