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Chernyak, Natalia; Dudnik, Alexander S; Huang, Chunhui; Gevorgyan, Vladimir
Journal of the American Chemical Society, 06/2010, Letnik: 132, Številka: 24Journal Article
A new general and easily installable silicon-tethered pyridyl-containing directing group (PyDipSi) that allows for highly efficient and regioselective Pd-catalyzed ortho C−H acyloxylation of arenes has been developed. It has also been demonstrated that this directing group can efficiently be removed as well as converted into a variety of other valuable functional groups. In addition, the installation of the PyDipSi directing group along with pivaloxylation and quantitative conversion of the PyDipSi group into a halogen functionality represents a formal three-step ortho oxygenation of haloarenes.
