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Bhat, Mamatha; Robichaud, Nathaniel; Hulea, Laura; Sonenberg, Nahum; Pelletier, Jerry; Topisirovic, Ivan
Nature reviews. Drug discover/Nature reviews. Drug discovery, 04/2015, Letnik: 14, Številka: 4Journal Article
Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents that target components of the protein synthesis apparatus hold promise as novel anticancer drugs that can overcome intra-tumour heterogeneity. In this Review, we discuss the role of translation in cancer, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and provide an overview of recent efforts aiming to 'translate' these results to the clinic.
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