E-viri
PDF
Recenzirano
Odprti dostop
-
Bezu, Lucillia; Sauvat, Allan; Humeau, Juliette; Leduc, Marion; Kepp, Oliver; Kroemer, Guido
Oncoimmunology, 06/2018, Letnik: 7, Številka: 6Journal Article
Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.
