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Rieger, Theodore R.; Allen, Richard J.; Musante, Cynthia J.
CPT: pharmacometrics & systems pharmacology, 20/May , Letnik: 10, Številka: 5Journal Article
Following this process, we generated 2500 parameter sets with a range of values that give rise to model simulations that are plausible. 5 Virtual populations are not a panacea for dealing with the uncertainty in QSP models. ...we would like to emphasize that the generation of virtual patients is not the end‐goal of QSP modeling, any more so than putting up a board is the end goal of carpentry. The synthesis of prior biology knowledge brings uncertainty, but also permits assessment of questions that are not amenable to minimal modeling, such as: evaluating novel combination therapies, extrapolation to longer trials, new indications, and identifying key areas of uncertainty for experiments.
