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de Miranda, João Antônio Leal; Martins, Conceição da Silva; Fideles, Lázaro de Sousa; Barbosa, Maria Lucianny Lima; Barreto, João Erivan Façanha; Pimenta, Helder Bindá; Freitas, Francisco Orlando Rafael; Pimentel, Paulo Vitor de Souza; Teixeira, Claudio Silva; Scafuri, Ariel Gustavo; Dos Santos Luciano, Maria Claudia; Araújo, Joabe Lima; Rocha, Jefferson Almeida; Vieira, Icaro Gusmão Pinto; Ricardo, Nágila Maria Pontes Silva; da Silva Campelo, Matheus; Ribeiro, Maria Elenir Nobre Pinho; de Castro Brito, Gerly Anne; Cerqueira, Gilberto Santos
Pharmaceuticals (Basel, Switzerland), 01/2020, Letnik: 13, Številka: 1Journal Article
Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from , has been reported as a potent antioxidant and anti-inflammatory agent. In the present study, we aimed to evaluate the effect of TRX on 5-FU-induced intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, TRX-50, TRX-100, TRX-150, Celecoxib (CLX), and CLX + TRX-100. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), mast and goblet cell counts, immunohistochemical analysis, and cyclooxygenase-2 (COX-2) activity. Compared to the saline treatment, the 5-FU treatment induced intense weight loss and reduction in villus height. TRX treatment (100 mg/kg) prevented the 5-FU-induced histopathological changes and decreased oxidative stress by decreasing the MDA levels and increasing GSH concentration. TRX attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. TRX also reversed the depletion of goblet cells. Our findings suggest that TRX at a concentration of 100 mg/kg had chemopreventive effects on 5-FU-induced intestinal mucositis via COX-2 pathway.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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