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Bacigalupo, Andrea; Angelucci, Emanuele; Raiola, Anna Maria; Varaldo, Riccardo; Di Grazia, Carmen; Gualandi, Francesca; Benedetti, Edoardo; Risitano, Antonio; Musso, Maurizio; Zallio, Francesco; Ciceri, Fabio; Chiusolo, Patrizia; Sica, Simona; Rambaldi, Alessandro; Bonifazi, Francesca; Parma, Matteo; Martino, Massimo; Onida, Francesco; Iori, Anna Paola; Selleri, Carmine; Borghero, Carlo; Bertaina, Alice; Prezioso, Lucia; Algeri, Mattia; Locatelli, Franco
Bone marrow transplantation (Basingstoke), 08/2020, Letnik: 55, Številka: 8Journal Article
We have treated 69 patients with steroid refractory acute graft versus host disease (SR-aGvHD), with an anti-CD26 monoclonal antibody (Begelomab): 28 patients in two prospective studies (EudraCT No. 2007-005809-21; EudraCT No. 2012-001353-19), and 41 patients on a compassionate use study. The median age of patients was 42 and 44 years; the severity of GvHD was as follows: grade II in 8 patients, grade III in 33, and grade IV in 28 patients. There were no adverse events directly attributable to the antibody. Day 28 response was 75% in the prospective studies and 61% in the compassionate use patients, with complete response rates of 11 and 12%. Response for grade III GvHD was 83 and 73% in the two groups; response in grade IV GvHD was 66 and 56% in the two groups. Non relapse mortality (NRM) at 6 months was 28 and 38%. Overall there were 64, 56, 68% responses for skin, liver, and gut stage 3-4 GvHD. The overall survival at 1 year was 50% for the prospective studies and 33% for the compassionate use patients. In conclusion, Begelomab induces over 60% responses in SR-aGvHD, including patients with severe gut and liver GvHD, having failed one or more lines of treatment.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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