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Tyrinova, T. V.; Batorov, E. V.; Aristova, T. A.; Ushakova, G. Yu; Sizikova, S. A.; Denisova, V. V.; Ostanin, A. A.; Chernykh, E. R.
Bulletin of experimental biology and medicine, 11/2022, Letnik: 174, Številka: 1Journal Article
We studied suppressor potential of myeloid-derived suppressor cells (MDSC) in multiple myeloma patients, including before and after mobilization of hematopoietic stem cells (HSC), by evaluating the expression of arginase-1 (Arg1), indolamine-2,3-dioxygenase (IDO), and PD-L1 in MDSC subsets. The study included 20 multiple myeloma patients in remission, 5 patients with progression, as well as 10 sex-and age-matched healthy donors. The expression of Arg1, IDO, and PD-L1 in circulating granulocytic MDSC (G-MDSC, Lin – HLA-DR – CD33 + CD66b + ), monocytic MDSC (M-MDSC, CD14 + HLA-DR low/– ), and early-stage MDSC (E-MDSC, Lin – HLA-DR – CD33 + CD66b – ) was evaluated by flow cytometry. Multiple myeloma patients in remission were characterized by reduced expression of Arg1 in M-MDSC in comparison with donors. The expression of Arg1 in M-MDSC depended on the number of induction therapy lines performed and was significantly lower in patients who received ⩾2 lines and responded with remission. Patients with multiple myeloma progression (resistant to therapy) showed significantly increased expression of Arg1 and PD-L1 in M-MDSC, as well as increased expression of Arg1 in E-MDSC. After G-CSF-induced mobilization of HSC, the content of circulating Arg1-expressing M-MDSC increased significantly. Considering the presence of MDSC in apheresis products, MDSC suppressive activity is discussed as a factor affecting the outcomes of autologous HSC transplantation in multiple myeloma patients.
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