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Resende, Paola Cristina; Gräf, Tiago; Paixão, Anna Carolina Dias; Appolinario, Luciana; Lopes, Renata Serrano; Mendonça, Ana Carolina da Fonseca; da Rocha, Alice Sampaio Barreto; Motta, Fernando Couto; Neto, Lidio Gonçalves Lima; Khouri, Ricardo; de Oliveira, Camila I; Santos-Muccillo, Pedro; Bezerra, João Felipe; Teixeira, Dalane Loudal Florentino; Riediger, Irina; Debur, Maria do Carmo; Ribeiro-Rodrigues, Rodrigo; Leite, Anderson Brandao; do Santos, Cliomar Alves; Gregianini, Tatiana Schäffer; Fernandes, Sandra Bianchini; Bernardes, André Felipe Leal; Cavalcanti, Andrea Cony; Miyajima, Fábio; Sachhi, Claudio; Mattos, Tirza; da Costa, Cristiano Fernandes; Delatorre, Edson; Wallau, Gabriel L; Naveca, Felipe G; Bello, Gonzalo; Siqueira, Marilda Mendonça
Viruses, 04/2021, Letnik: 13, Številka: 5Journal Article
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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