Abbreviations AGEs advanced glycation endproducts BMI body mass index CEL N-epsilon-(1-carboxyethyl)-lysine CI confidence intervals CML N-epsilon-(carboxymethyl)-lysine DQ dietary questionnaires EPIC European Prospective Investigation into Cancer and Nutrition HR hazard ratios MG-H1 N-delta-5-hydro-5-methyl-4-imidazolon-2-yl-ornithine RAGE receptor of AGEs SD standard deviation sRAGE soluble receptor of AGEs UPLC-MS/MS ultra-performance liquid chromatography-tandem mass spectrometry Dear Editor, In the European region, which shares 22.8% of the global cancer burden for 10% of the global population, there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020 1. Previous clinical and experimental studies suggested that AGEs are proinflammatory, increase oxidative stress and activate pro-carcinogenic transcription factors such as NFκB and STAT3 as well as cell signaling pathways like mitogen-activated protein kinase (MAPK) by binding on the receptor for AGEs (RAGE) 7. ...there always remains the possibility of unmeasured confounding. ...in this large multinational prospective cohort study across 20 anatomical cancer sites, a higher intake of dietary AGEs was not associated with an increased risk of overall cancer and most cancer types studied.