Ezetimibe and Simvastatin Reduce Inflammation, Disease Activity, Aortic Stiffness and Improve Endothelial Function in Rheumatoid Arthritis Kaisa M. Mäki-Petäjä, Anthony D. Booth, Frances C. Hall, Sharon M. L. Wallace, John Brown, Carmel M. McEniery, Ian B. Wilkinson This study demonstrates that both ezetimibe and simvastatin reduce disease activity, inflammatory markers, and aortic pulse wave velocity and improve endothelial function in patients with rheumatoid arthritis (RA). These results suggest that the reduction of cholesterol per se ameliorates aortic stiffness and endothelial dysfunction. The data indicate that cholesterol-reducing therapies may be beneficial for RA patients, because they are well tolerated, improve clinical outcome, and reduce surrogates of cardiovascular risk.