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Besarab, Anatole; Bolton, W. Kline; Browne, Jeffrey K; Egrie, Joan C; Nissenson, Allen R; Okamoto, Douglas M; Schwab, Steve J; Goodkin, David A
The New England journal of medicine, 08/1998, Letnik: 339, Številka: 9Journal Article
Advanced kidney failure usually leads to anemia, primarily as a result of deficient renal erythropoietin production. Most patients undergoing hemodialysis are treated with recombinant human erythropoietin (epoetin) to stimulate erythropoiesis and correct the anemia partially. In a random sample of 940 patients at 188 U.S. hemodialysis centers obtained before the initiation of this study, we found that 69 percent of the patients had hematocrits of 27 to 33 percent, 15 percent had values below 27 percent, and 16 percent had values above 33 percent (unpublished data). Yet the normal ranges for hematocrit values are 37 to 48 percent for women . . .
