E-viri
Recenzirano
Odprti dostop
-
Vegliante, Maria Carmela; Mazzara, Saveria; Zaccaria, Gian Maria; Summa, Simona; Esposito, Flavia; Melle, Federica; Motta, Giovanna; Sapienza, Maria Rosaria; Opinto, Giuseppina; Volpe, Giacomo; Bucci, Antonella; Gargano, Grazia; Enjuanes, Anna; Tabanelli, Valentina; Fiori, Stefano; Minoia, Carla; Clemente, Felice; Negri, Antonio; Gulino, Alessandro; Morello, Gaia; Scattone, Anna; Zito, Alfredo F.; Tommasi, Stefania; Agostinelli, Claudio; Vitolo, Umberto; Chiappella, Annalisa; Barbui, Anna Maria; Derenzini, Enrico; Zinzani, Pier Luigi; Casadei, Beatrice; Rivas‐Delgado, Alfredo; López‐Guillermo, Armando; Campo, Elias; Moschetta, Antonio; Guarini, Attilio; Pileri, Stefano A.; Ciavarella, Sabino
Hematological oncology, December 2022, Letnik: 40, Številka: 5Journal Article
The role of macrophages (Mo) and their prognostic impact in diffuse large B‐cell lymphomas (DLBCL) remain controversial. By regulating the lipid metabolism, Liver‐X‐Receptors (LXRs) control Mo polarization/inflammatory response, and their pharmacological modulation is under clinical investigation to treat human cancers, including lymphomas. Herein, we surveyed the role of LXRs in DLBCL for prognostic purposes. Comparing bulk tumors with purified malignant and normal B‐cells, we found an intriguing association of NR1H3, encoding for the LXR‐α isoform, with the tumor microenvironment (TME). CIBERSORTx‐based purification on large DLBCL datasets revealed a high expression of the receptor transcript in M1‐like pro‐inflammatory Mo. By determining an expression cut‐off of NR1H3, we used digital measurement to validate its prognostic capacity on two large independent on‐trial and real‐world cohorts. Independently of classical prognosticators, NR1H3high patients displayed longer survival compared with NR1H3low cases and a high‐resolution Mo GEP dissection suggested a remarkable transcriptional divergence between subgroups. Overall, our findings indicate NR1H3 as a Mo‐related biomarker identifying patients at higher risk and prompt future preclinical studies investigating its mouldability for therapeutic purposes.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.