In order to provide a comprehensive evaluation of the non‐genetic factors involved in the development of Alzheimer’s disease and related disorders it is necessary to develop a systematic process to capture the range of environmental and social influences. Exposomics has emerged as an approach to do this. Using high‐resolution mass spectrometry and geospatial techniques it is possible to evaluate thousands of external factors (chemical, nutritional, social, environmental) and their corresponding impact on biology. In this presentation, we will describe the steps we are taking to build the required infrastructure. The first aspect is to improve the identification of exogenous and endogenous chemical features by expansion of our high‐resolution mass spectrometry capabilities (automated liquid handling with ThermoFisher Orbitrap‐based technology: HFX, LC‐Exploris 240, GC‐Exploris 240, and IQX Tribrid Mass Spectrometer). We are in the process of analyzing thousands of samples from WHICAP, EFIGA, and RANN using our combined LC/GC Orbitrap platform, to identify significant associations with disease traits (existing and next generation biomarkers, pathology, imaging, clinical features). Initial results from these studies will be presented to demonstrate feasibility of the approach. We have also initiated a series of pilot studies for other AD cohorts, which cover a range of populations with diverse ethnicity, disease stage, and age. These studies have extensive clinical phenotyping and deep molecular phenotyping. The addition of exposomics will leverage these existing studies to uncover novel environmental contributors to AD. We also also developing a platform to distribute workflows via an online EXCEL AD Community Dashboard to other ADRCs and AD research groups interested in incorporating exposomics into their studies. We will also provide guidance on quality control materials, including providing standards as needed. The Community Dashboard would also compile information on ongoing AD studies that are incorporating exposomics, as well as relevant publications. Various tools will be developed to encourage the utilization of this new platform such as user manuals, training programs (in‐person, online) exposomics bootcamps, and scholar exchange through on‐site visits to laboratories. We will deploy an academic research consultancy that will help other interested laboratories to establish the exposomics workflow.