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McNeill, Luke A; Flashman, Emily; Buck, Matthew R G; Hewitson, Kirsty S; Clifton, Ian J; Jeschke, Gunnar; Claridge, Timothy D W; Ehrismann, Dominic; Oldham, Neil J; Schofield, Christopher J
Molecular bioSystems, 10/2005, Letnik: 1, Številka: 4Journal Article
Regulation of the hypoxic response in humans is regulated by the post-translational hydroxylation of hypoxia inducible transcription factor; a recombinant form of a human prolyl-4-hydroxylase (PHD2) was characterised and shown to have an unexpectedly high affinity for, and to copurify with endogenous levels of, its Fe(ii) cofactor and 2-oxoglutarate cosubstrate.
