The thermal transport properties of an iron-doped molybdenum disulfide system were explored theoretically using the density functional theory calculations combined with the Keldysh non-equilibrium Green's function approach. The results indicate that a perfect spin filtering effect and spin Seebeck effect are induced thermally. Excellently, there exists thermal colossal magnetoresistances, which exhibit a transition between positive and negative that can be tuned using temperature. These features were elucidated using the band structures of the electrodes and the transmission function together with current spectra. Our findings may be helpful in the design of highly efficient spin caloritronic devices. The thermal transport properties of an iron-doped molybdenum disulfide system were explored theoretically using the density functional theory calculations combined with the Keldysh non-equilibrium Green's function approach.