E-viri
Recenzirano
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di Luca, Mariagrazia; Curcio, Manuela; Valli, Emanuele; Cirillo, Giuseppe; Voli, Florida; Butini, Maria Eugenia; Farfalla, Annafranca; Pantuso, Elvira; Leggio, Antonella; Nicoletta, Fiore Pasquale; Tavanti, Arianna; Iemma, Francesca; Vittorio, Orazio
Journal of materials chemistry. B, Materials for biology and medicine, 07/2019, Letnik: 7, Številka: 27Journal Article
A multi-functional composite to be employed as a dressing material was prepared by combining hydrogel and microparticle systems. For the synthesis of the hydrogel counterpart, a free radical polymerization was carried out using a gelatin-curcumin conjugate, previously obtained through immobilized laccase catalysis, and polyethylene glycol dimethacrylate as a functional element, plasticizer, and crosslinker. The hydrogel was found to possess high water affinity, biocompatibility, and the ability to reduce the H 2 O 2 -induced oxidative stress on MRC-5 cells by 30%. The spherical microparticle system (mean diameter of 1.75 μm) was prepared by self-assembly of a keratin-methacrylated polyethylene glycol-40 stearate derivative synthesized by a free radical reaction. The final composite, prepared by absorption of microparticles on the hydrogel system, was found to be effective as a support for enhanced cell growth (3.5 times). Furthermore, a reduction of methicillin-resistant Staphylococcus aureus proliferation by 1 log 10 CFU was reached taking advantage of the sustained release of the antimicrobial quercetin. A multi-functional composite to be employed as a dressing material was prepared by combining hydrogel and microparticle systems.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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