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Longley, Rhea J; White, Michael T; Takashima, Eizo; Brewster, Jessica; Morita, Masayuki; Harbers, Matthias; Obadia, Thomas; Robinson, Leanne J; Matsuura, Fumie; Liu, Zoe S J; Li-Wai-Suen, Connie S N; Tham, Wai-Hong; Healer, Julie; Huon, Christele; Chitnis, Chetan E; Nguitragool, Wang; Monteiro, Wuelton; Proietti, Carla; Doolan, Denise L; Siqueira, Andre M; Ding, Xavier C; Gonzalez, Iveth J; Kazura, James; Lacerda, Marcus; Sattabongkot, Jetsumon; Tsuboi, Takafumi; Mueller, Ivo
Nature Medicine, 05/2020, Letnik: 26, Številka: 5Journal Article, Magazine Article
A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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