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Recenzirano
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Muñoz-Calleja, C; Costantini, A; Silvestri, G; Butini, L; Regnery, C M; Mancini, S; Montroni, M
AIDS (London), 09/2001, Letnik: 15, Številka: 14Journal Article
Highly active antiretroviral therapy (HAART) improves the immunodeficiency of HIV-infected individuals. In this report we show that HAART increases both naive (CD45RA+CD62L+) and central memory (CD45RO+CD62L+) CD4 lymphocytes. On CD8 lymphocytes, HAART induces an increase of naive cells associated with a consistent decrease of effector cells (CD45 RO+CD62L-). No specific differences in phenotypic changes were observed with different HAART regimens, suggesting that, once viral suppression is achieved, the pharmacological class of antiretroviral drugs does not affect immune reconstitution.
