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Hodge, James W; Ardiani, Andressa; Farsaci, Benedetto; Kwilas, Anna R; Gameiro, Sofia R
Seminars in oncology, 06/2012, Letnik: 39, Številka: 3Journal Article
Therapeutic cancer vaccines are a unique treatment modality in that they initiate a dynamic process of activating the host immune system, which can then be exploited by concurrent or subsequent therapies. The addition of immunotherapy to standard-of-care cancer therapies has shown evidence of efficacy in preclinical models and in the clinical setting. This review examines the preclinical and clinical interactions between vaccine-mediated tumor-specific immune responses and local radiation, systemic chemotherapy, or select small molecule inhibitors, as well as the potential synergy between these modalities.
