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Jean-Baptiste, KANGAH Niameke; Guillaume, KODJO Charles; Adama, OUATTARA Zana; Claude, KABLAN Ahmont Landry; Jacques, DIBI Konan; Antoine, KOUAME Bosson; Nahosse, Ziao
IRA-International Journal of Applied Sciences (ISSN 2455-4499), 05/2017, Letnik: 7, Številka: 2Journal Article
We report herein synthesis, characterization and antimicrobial activity of four Shiff bases derived from hexamethylenediamine. Substitution of a nitro group on each aromatic ring in ortho, meta or para positions of N,N'-bis(phenylmethyl)hexane-1,6-diimineallowed to have a homogeneous series of positional isomers. These four symmetric diimine Schiff bases were characterized by conventional spectrometry methods (NMR, IR, MS), then tested against Gram-positive and Gram-negative bacterial strains. Among them, compounds 1b, 1c, 1d were found to be active against bacterial strain Staphylococcus aureus CIP with MIC value of 375μg/ ml, 187.5μg /ml and 375μg /ml respectively. Candida Albicans fungal strain showed resistance to all synthesized Schiff base compounds, butin the other hand, Candida glabrata has been sensitive to all compounds with MIC of 1500μg/ ml and one more time except 1a.
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