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Samarin, S.I.; Konovalov, A.B.; Vlasov, V.V.; Solovyev, I.D.; Savitsky, A.P.; Tuchin, V.V.
Kompʹûternaâ optika, 10/2023, Letnik: 47, Številka: 5Journal Article
The paper describes a TurbidMC code that implements a perturbative Monte Carlo method to model temporal point spread functions and sensitivity functions for time-resolved fluorescence molecular tomography (FMT). The code is aimed at working with a particular FMT method published earlier (Ref. 22) which defines the specificity of sensitivity function calculation. The method solves the inverse problem first for a generalized fluorescence parameter distribution function and then calculates separate distributions for the fluorophore absorption coefficient and the fluorescence lifetime. The proper operation of the code was verified through a comparison between fluorescence temporal point spread functions from test calculations and data from experiments where a phantom with a fluorophore was scanned with a three-channel probe in the mesoscopic reflectance regime. An example is given on the reconstruction of fluorescence parameter distributions. It shows that the sensitivity functions are calculated correctly.
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