Chosen-ciphertext security is a central goal in designing a secure public-key encryption scheme, and it is also important that the chosen-ciphertext security is tightly reduced to some well-established hard problem. Moreover, it is more important to have a tight reduction in the multi-user multi-challenge setting, since a tight security reduction in the single-user single-challenge setting generally does not imply a tight reduction to the multi-user multi-challenge setting. We propose the first fully tightly secure and practical public-key encryption scheme which is chosen-ciphertext secure in the multi-user multi-challenge setting in the random oracle model. The scheme is proven secure under the decisional Diffie-Hellman assumption in a pairing-free group. The ciphertext overhead of our scheme is two group elements and two exponents.