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DiToro, Daniel; Winstead, Colleen J; Pham, Duy; Witte, Steven; Andargachew, Rakieb; Singer, Jeffrey R; Wilson, C Garrett; Zindl, Carlene L; Luther, Rita J; Silberger, Daniel J; Weaver, Benjamin T; Kolawole, E Motunrayo; Martinez, Ryan J; Turner, Henrietta; Hatton, Robin D; Moon, James J; Way, Sing Sing; Evavold, Brian D; Weaver, Casey T
Science (American Association for the Advancement of Science), 09/2018, Letnik: 361, Številka: 6407Journal Article
In response to infection, naïve CD4 T cells differentiate into two subpopulations: T follicular helper (T ) cells, which support B cell antibody production, and non-T cells, which enhance innate immune cell functions. Interleukin-2 (IL-2), the major cytokine produced by naïve T cells, plays an important role in the developmental divergence of these populations. However, the relationship between IL-2 production and fate determination remains unclear. Using reporter mice, we found that differential production of IL-2 by naïve CD4 T cells defined precursors fated for different immune functions. IL-2 producers, which were fated to become T cells, delivered IL-2 to nonproducers destined to become non-T cells. Because IL-2 production was limited to cells receiving the strongest T cell receptor (TCR) signals, a direct link between TCR-signal strength, IL-2 production, and T cell fate determination has been established.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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