In this article, we approach strategic technology management from the perspective of the quintuple innovation helix with embedded AI modalities as it applies to public interest technologies (PIT) and we focus on the use cases of semiconductors, fusion, and AI per se. We have named this methodology the Quintuple Innovation Helix plus AI (QIH+AI). The need for an increasingly sophisticated and dynamic balancing act between techno-centric and human-centric design philosophies. These paradigms include the Industry 5.0 (more techno-centric) and the Society 5.0 (more human-centric) paradigm as well as the emerging Industry 6.0 and Society 6.0 paradigms where the presence, role and influence of AI modalities are rather substantive and even omnipresent. In this article, we develop and propose the QIH+AI methodology as a powerful tool for strategic technology road mapping. This article provides a comprehensive framework for all stakeholders to address the question of "how to" effectively navigate the complexities of strategic technology management in an uncertain environment.