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Hou, Mimi M; Barrett, Jordan R; Themistocleous, Yrene; Rawlinson, Thomas A; Diouf, Ababacar; Martinez, Francisco J; Nielsen, Carolyn M; Lias, Amelia M; King, Lloyd D W; Edwards, Nick J; Greenwood, Nicola M; Kingham, Lucy; Poulton, Ian D; Khozoee, Baktash; Goh, Cyndi; Hodgson, Susanne H; Mac Lochlainn, Dylan J; Salkeld, Jo; Guillotte-Blisnick, Micheline; Huon, Christèle; Mohring, Franziska; Reimer, Jenny M; Chauhan, Virander S; Mukherjee, Paushali; Biswas, Sumi; Taylor, Iona J; Lawrie, Alison M; Cho, Jee-Sun; Nugent, Fay L; Long, Carole A; Moon, Robert W; Miura, Kazutoyo; Silk, Sarah E; Chitnis, Chetan E; Minassian, Angela M; Draper, Simon J
Science translational medicine, 07/2023, Letnik: 15, Številka: 704Journal Article
There are no licensed vaccines against . We conducted two phase 1/2a clinical trials to assess two vaccines targeting Duffy-binding protein region II (PvDBPII). Recombinant viral vaccines using chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) vectors as well as a protein and adjuvant formulation (PvDBPII/Matrix-M) were tested in both a standard and a delayed dosing regimen. Volunteers underwent controlled human malaria infection (CHMI) after their last vaccination, alongside unvaccinated controls. Efficacy was assessed by comparisons of parasite multiplication rates in the blood. PvDBPII/Matrix-M, given in a delayed dosing regimen, elicited the highest antibody responses and reduced the mean parasite multiplication rate after CHMI by 51% ( = 6) compared with unvaccinated controls ( = 13), whereas no other vaccine or regimen affected parasite growth. Both viral-vectored and protein vaccines were well tolerated and elicited expected, short-lived adverse events. Together, these results support further clinical evaluation of the PvDBPII/Matrix-M vaccine.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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