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Pereira, Joana B; Janelidze, Shorena; Strandberg, Olof; Whelan, Christopher D; Zetterberg, Henrik; Blennow, Kaj; Palmqvist, Sebastian; Stomrud, Erik; Mattsson-Carlgren, Niklas; Hansson, Oskar
Nature aging, 12/2022, Letnik: 2, Številka: 12Journal Article
The role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying Alzheimer's disease (AD) . Here, we measured the microglial marker soluble TREM2 and the disease-associated microglial activation stage 2 markers AXL, MERTK, GAS6, LPL, CST7, SPP1 and CSF1 in nondemented individuals from the Swedish BioFINDER-2 cohort who underwent longitudinal tau-positron emission tomography (PET), amyloid-PET and global cognitive assessment. To assess whether baseline microglial markers had an effect on AD-related changes, we studied three sub-groups of individuals: 121 with evidence of amyloid-PET pathology (A ), 64 with additional evidence of tau-PET pathology (A T ) and 159 without amyloid- or tau-PET pathology (A T ). Our results showed that increased levels of TREM2 were associated with slower amyloid accumulation in A individuals in addition to slower tau deposition and cognitive decline in A T subjects. Similarly, higher levels of AXL, MERTK, GAS6, LPL, CST7 and CSF1 predicted slower tau accumulation and/or cognitive decline in the A T group. These findings have important implications for future therapeutic strategies aiming to boost microglial protective functions in AD.
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in: SICRIS
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