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Li, Guo-Bo; Brem, Jürgen; Lesniak, Robert; Abboud, Martine I; Lohans, Christopher T; Clifton, Ian J; Yang, Sheng-Yong; Jiménez-Castellanos, Juan-Carlos; Avison, Matthew B; Spencer, James; McDonough, Michael A; Schofield, Christopher J
Chemical communications (Cambridge, England), 05/2017, Letnik: 53, Številka: 43Journal Article
Crystallographic analyses of the VIM-5 metallo-β-lactamase (MBL) with isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other MBL-inhibitor structures directed addition of a zinc-binding thiol enabling identification of potent B1 MBL inhibitors. The inhibitors potentiate meropenem activity against clinical isolates harboring MBLs.
