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Takeda, Hiroaki; Nishise, Shoichi; Fukui, Tadahisa; Fujishima, Shoichiro; Orii, Tomohiko; Otake, Sayaka; Sato, Takeshi; Sasaki, Yu; Kawata, Sumio
Hepato-gastroenterology, 03/2009, Letnik: 56, Številka: 90Journal Article
Cytapheresis with extra-corporeal circulation for ulcerative colitis is effective but its mechanisms are still unclear. Granulocytecolony stimulating factor (G-CSF) strongly mobilizes bone marrow-derived cells and serves as antiinflammatory factor. We investigated plasma levels of G-CSF during granulocyte and monocyte adsorptive apheresis (GCAP). Nineteen cases of ulcerative colitis were measured plasma concentration of G-CSF during the first session of GCAP therapy. G-CSF were significantly increased in the column inflow at 30 min compared with the baseline (Wilcoxon test, p < 0.01), and also increased through the column (Wilcoxon test, p < 0.01). The ratio of the increase in the column outflow at 60 min was 1.5-fold compared with the baseline. However, we could not show a significant relation between G-CSF level and clinical efficacy. This is the first report concerning G-CSF during CAP. G-CSF is increased due to GCAP and appears to be a candidate which should be further investigated.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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