Na pojavu i štete od kukuruznog moljca kao jednog od najvažnijih štetnika kukuruza mogu utjecati različiti čimbenici. Istraživanje utjecaja sustava obrade tla i gnojidbe kukuruza na napad i štete od kukuruznog moljca provedeno je 2021. godine na pokusnim površinama Veleučilišta u Križevcima. Tretmani u pokusu bili su: standardna obrada tla (ST), konzervacijski sustav plitki (KSP) i konzervacijski sustav duboki (KSD), gnojidba prema preporuci (GPP), GPP s dodatkom biofoziološkog aktivatora (GPPGEO) te gnojidba umanjena za 50% (GU) i GU s dodatkom biofoziološkog aktivatora (GUGEO). Rezultati istraživanja su pokazali da sustav obrade tla, gnojidba kukuruza i njihove interakcije imaju značajan utjecaj na većinu, ali ne na sve mjerene parametre oštećenja od kukuruznog moljca (postotak zaraze stabljike, drške klipa i klipa, broj rupa i ukupna dužina oštećenja, broj gusjenica po biljci). Varijante ST, GPPGEO i GPP te njihove interakcije rezultirale su najvećim intenzitetom zaraze u većini parametara. Sustav obrade tla nije imao značajan učinak na postotak zaraze drške klipa, a gnojidba nije imala utjecaja na postotak zaraženih stabljika i broj gusjenica po biljci. Najveća masa klipa po biljci utvrđena je kod tretmana obrade tla KSP i ST, kod gnojidbe GPPGEO i GPP te u interakcijama KSP i GPP te ST i GPPGEO. The infestation and damage caused by the European corn borer (ECB), as one of the most important pests of corn, are influenced by various factors. Research on the impact of different soil tillage systems and corn fertilization on attack and damage of ECB was conducted in year 2021 in Križevci (NW Croatia). The influence of conventional tillage (ST), deep loosening (CTD shallow loosening (CTS), fertilization as recommended (FR), FR with addition of biophysiological activator Geo2 (FRG) and fertilization reduced by 50% (F50%) and F50% with addition (F50%G)) of biophysiological activator were determined. The results of the research showed that the tillage system, corn fertilization and their interactions have a significant influence on most of the measured parameters of intensity of infestation from the ECB (percentage of stem, ear shank and ear infestation, number and length of holes in stalk, number of caterpillars per plant), but not for all. Variants ST, FRG and FR and their interactions resulted in the highest infestation intensity in most parameters, but the tillage system had no significant effect on the percentage of ear shank infestation, and fertilization did not affect the percentage of stalk infestation and the number of caterpillars per plant. The highest ear mass per plant was found in soil treatment CTS and ST, in fertilization FRG and FR and in the interactions of CTS and FR and ST and FRG.