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Ishikawa, Ryo; Yasuda, Mizuho; Sasaki, Shogo; Ma, Yue; Nagasawa, Kazuo; Tera, Masayuki
Chemical communications (Cambridge, England), 07/2021, Letnik: 57, Številka: 59Journal Article
The extent of thermodynamic stabilization of telomeric G-quadruplex (G4) by isomers of G4 ligand L2H2-6OTD, a telomestatin analog, is inversely correlated with susceptibility to S1 nuclease. L2H2-6OTD facilitated the S1 nuclease activities through the base flipping in G4, unlike the conventional role of G4 ligands which inhibit the protein binding to DNA/RNA upon ligand interactions. The ligand binding to the telomeric G-quadruplex enhanced susceptibility to S1 nuclease through the base flipping.
