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Huang, Keke; Jia-Ni, Li; Qiu, Guanyinsheng; Xie, Wenlin; Liu, Jin-Biao
RSC advances, 10/2019, Letnik: 9, Številka: 57Journal Article
In this work, a selective synthetic strategy towards 1-azaspiro4.5deca-3,6,9-trien-8-ones from N-tosyl-N-(prop-2-yn-1-yl)aniline is developed. The transformation proceeds smoothly in a mixed solvent including acetonitrile and water when ZnBr2 and Oxone are employed. Mechanism studies show that the reaction proceeds in a regioselective manner via a radical ipso-cyclization pathway.
