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Liang, Joshua G; Su, Danmei; Song, Tian-Zhang; Zeng, Yilan; Huang, Weijin; Wu, Jinhua; Xu, Rong; Luo, Peiwen; Yang, Xiaofang; Zhang, Xiaodong; Luo, Shuangru; Liang, Ying; Li, Xinglin; Huang, Jiaju; Wang, Qiang; Huang, Xueqin; Xu, Qingsong; Luo, Mei; Huang, Anliang; Luo, Dongxia; Zhao, Chenyan; Yang, Fan; Han, Jian-Bao; Zheng, Yong-Tang; Liang, Peng
Nature communications, 03/2021, Letnik: 12, Številka: 1Journal Article
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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