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Patel, Manish M; Jackson, Michael L; Ferdinands, Jill
JAMA : the journal of the American Medical Association, 11/2020, Letnik: 324, Številka: 19Journal Article
This Viewpoint explains the "test-negative" modified case-control design commonly used for evaluating vaccine effectiveness, describes why it may be lead to biased estimates of COVID-19 vaccine effectiveness in patients with severe illness more likely to test negative, and proposes potential approaches to correcting the bias, including incorporation of clinical assessment of cases.
