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Chan, Ho-Fung; Smith, Laurie J; Biancardi, Alberto M; Bray, Jody; Marshall, Helen; Hughes, Paul J C; Collier, Guilhem J; Rao, Madhwesha; Norquay, Graham; Swift, Andrew J; Hart, Kylie; Cousins, Michael; Watkins, W John; Wild, Jim M; Kotecha, Sailesh
American journal of respiratory and critical care medicine, 01/2023, Letnik: 207, Številka: 1Journal Article
Chan et al examined the differential associations between the historical diagnosis of bronchopulmonary dysplasia (BPD) and current lung function phenotypes on lung ventilation and microstructure in preterm-born children using hyperpolarized Xe ventilation and diffusion-weighted magnetic resonance imaging (MRI) and multiple-breath washout (MBW). Xe ventilation defect percentage and ventilation heterogeneity index were significantly increased in preterm-born children with prematurity-associated obstructive lung disease (POLD). They show that ventilation abnormalities are associated with POLD, and BPD in infancy is associated with abnormal lung microstructure.
