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AISEN, P. S; ANDRIEU, S; HENDRIX, S. B; GRUNDMAN, M; SCHNEIDER, L. S; SCHINDLER, R. J; SALMON, E; POTTER, W. Z; THOMAS, R. G; SALMON, D; DONOHUE, M; BEDNAR, M. M; SAMPAIO, C; TOUCHON, J; VELLAS, B; CARRILLO, M; KHACHATURIAN, Z. S; DUBOIS, B; FELDMAN, H. H; PETERSEN, Rc; SIEMERS, E; DOODY, R. S
Neurology, 01/2011, Letnik: 76, Številka: 3Journal Article, Web Resource
A large number of promising candidate disease-modifying treatments for Alzheimer disease (AD) continue to advance into phase II and phase III testing. However, most completed trials have failed to demonstrate efficacy, and there is growing concern that methodologic difficulties may contribute to these clinical trial failures. The optimal time to intervene with such treatments is probably in the years prior to the onset of dementia, before the neuropathology has progressed to the advanced stage corresponding to clinical dementia. An international task force of individuals from academia, industry, nonprofit foundations, and regulatory agencies was convened to discuss optimal trial design in early (predementia) AD. General consensus was reached on key principles involving the scope of the AD diagnosis, the selection of subjects for trials, outcome measures, and analytical methods. A consensus has been achieved in support of the testing of candidate treatments in the early (predementia) AD population.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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