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Le, Hien-Phuong; Hassan, Kamrul; Ramezanpour, Mahnaz; Campbell, Jonathan A; Tung, Tran Thanh; Vreugde, Sarah; Losic, Dusan
Journal of materials chemistry. B, Materials for biology and medicine, 07/2024, Letnik: 12, Številka: 27Journal Article
The advent of three-dimensional (3D) bioprinting offers a feasible approach to construct complex structures for soft tissue regeneration. Carboxymethyl cellulose (CMC) has been emerging as a very promising biomaterial for 3D bioprinting. However, due to the inability to maintain the post-printed stability, CMC needs to be physically blended and/or chemically crosslinked with other polymers. In this context, this study presents the combination of CMC with xanthan gum (XG) and hyaluronic acid (HA) to formulate a multicomponent bioink, leveraging the printability of CMC and XG, as well as the cellular support properties of HA. The ionic crosslinking of printed constructs with iron( iii ) via the metal-ion coordination between ferric cations and carboxylate groups of the three polymers was introduced to induce improved mechanical strength and long-term stability. Moreover, immortalized human epidermal keratinocytes (HaCaT) and human foreskin fibroblasts (HFF) encapsulated within iron-crosslinked printed hydrogels exhibited excellent cell viability (more than 95%) and preserved morphology. Overall, the presented study highlights that the combination of these three biopolymers and the ionic crosslinking with ferric ions is a valuable strategy to be considered for the development of new and advanced hydrogel-based bioinks for soft tissue engineering applications. A new hybrid crosslinked bioink for soft tissue engineering has been developed by combining carboxymethyl cellulose, xanthan gum and hyaluronic acid incorporating ferric-ion coordination with the carboxylate groups of these three polysaccharides.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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