An enantiomerically pure BINOL‐based bis(3‐pyridyl) ligand 1 assembles into a homochiral Pd4(1)8 complex upon coordination to tetravalent PdII ions. The formation of this aggregate is templated by two tetrafluoroborate counterions that are encapsulated in two peripheral cavities. The resulting structure is a new structural motif for this kind of metallosupramolecular assemblies that arranges the palladium ions in a distorted tetrahedral fashion and forces ligand 1 to adopt two different conformations. Both phenomena are unique and cause an overall three‐dimensional structure that has another confined, chiral, and hydrophilic central cavity. Close association: A BINOL‐based bis(3‐pyridyl) ligand assembles into a Pd4L8 complex upon coordination to PdII ions. The formation of the aggregate is templated by two BF4− ions that are encapsulated in peripheral cavities. The palladium ions are arranged in a distorted tetrahedral fashion, which forces the ligand to adopt two different conformations (see picture).