Froehlich discusses medication treatments for preschool children with attention-deficit/hyperactivity disorder (ADHD). Recognition of ADHD in the preschool age group is on the rise, with an increase in preschool ADHD rates in US nationally representative samples from 1.0% in 2007 to 2008 to 2.4% in 2016.1 Having a preschool-age child (ie, 3-5 years) with ADHD is associated with numerous negative outcomes in the home (eg, disordered parent-child relationships, elevated family stress2) as well as out-of-home settings (eg, impaired preacademic skills, peer interaction difficulties, expulsion from preschool and childcare settings), underscoring the importance of identification and treatment. Guidelines from the American Academy of Pediatrics and the Society for Developmental-Behavioral Pediatrics (SDBP) recommend behavioral interventions as first-line treatment for preschool-age children with ADHD.