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Liu, Junxi; Richmond, Rebecca C; Anderson, Emma L; Bowden, Jack; Barry, Ciarrah-Jane S; Dashti, Hassan S; Daghlas, Iyas S; Lane, Jacqueline M; Kyle, Simon D; Vetter, Céline; Morrison, Claire L; Jones, Samuel E; Wood, Andrew R; Frayling, Timothy M; Wright, Alison K; Carr, Matthew J; Anderson, Simon G; Emsley, Richard A; Ray, David W; Weedon, Michael N; Saxena, Richa; Rutter, Martin K; Lawlor, Deborah A
Scientific reports, 06/2024, Letnik: 14, Številka: 1Journal Article
Abstract Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian randomization (MR) studies support an effect of self-reported insomnia, but not others, on glycated haemoglobin (HbA1c). To explore potential effects, we used MR methods to assess effects of accelerometer-derived sleep traits (duration, mid-point least active 5-h, mid-point most active 10-h, sleep fragmentation, and efficiency) on HbA1c/glucose in European adults from the UK Biobank (UKB) (n = 73,797) and the MAGIC consortium (n = 146,806). Cross-trait linkage disequilibrium score regression was applied to determine genetic correlations across accelerometer-derived, self-reported sleep traits, and HbA1c/glucose. We found no causal effect of any accelerometer-derived sleep trait on HbA1c or glucose. Similar MR results for self-reported sleep traits in the UKB sub-sample with accelerometer-derived measures suggested our results were not explained by selection bias. Phenotypic and genetic correlation analyses suggested complex relationships between self-reported and accelerometer-derived traits indicating that they may reflect different types of exposure. These findings suggested accelerometer-derived sleep traits do not affect HbA1c. Accelerometer-derived measures of sleep duration and quality might not simply be ‘objective’ measures of self-reported sleep duration and insomnia, but rather captured different sleep characteristics.
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