Evidence is presented, based on an ensemble of climate change scenarios performed with a global general circulation model of the atmosphere with high horizontal resolution over Europe, to suggest that the end-of-century anthropogenic climate change over the North Atlantic–European region strongly projects onto the positive phase of the North Atlantic Oscillation during wintertime. It is reflected in a doubling of the residence frequency of the climate system in the associated circulation regime, in agreement with the nonlinear climate perspective. The strong increase in the amplitude of the response, compared to coarse-resolution coupled model studies, suggests that improved model representation of regional climate is needed to achieve more reliable projections of anthropogenic climate change on European climate.