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  • Dissociating Statistically ...
    Matusz, Emily F.; Price, Catherine C.; Lamar, Melissa; Swenson, Rod; Au, Rhoda; Emrani, Sheina; Wasserman, Victor; Libon, David J.; Thompson, Louisa I.

    Journal of the International Neuropsychological Society, 02/2023, Letnik: 29, Številka: 2
    Journal Article

    To determine whether the DCTclock can detect differences across groups of patients seen in the memory clinic for suspected dementia. Patients ( = 123) were classified into the following groups: cognitively normal (CN), subtle cognitive impairment (SbCI), amnestic cognitive impairment (aMCI), and mixed/dysexecutive cognitive impairment (mx/dysMCI). Nine outcome variables included a combined command/copy total score and four command and four copy indices measuring drawing efficiency, simple/complex motor operations, information processing speed, and spatial reasoning. Total combined command/copy score distinguished between groups in all comparisons with medium to large effects. The mx/dysMCI group had the lowest total combined command/copy scores out of all groups. The mx/dysMCI group scored lower than the CN group on all command indices (  < .050, all analyses); and lower than the SbCI group on drawing efficiency (  = .011). The aMCI group scored lower than the CN group on spatial reasoning (  = .019). Smaller effect sizes were obtained for the four copy indices. These results suggest that DCTclock command/copy parameters can dissociate CN, SbCI, and MCI subtypes. The larger effect sizes for command clock indices suggest these metrics are sensitive in detecting early cognitive decline. Additional research with a larger sample is warranted.